Tecentriq (Atezolizumab)

Description

Tecentriq (Atezolizumab) is a monoclonal antibody medication. It is primarily used to treat different types of cancer, such as non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), hepatocellular carcinoma, and alveolar soft part sarcoma. It is classified as a programmed death-ligand 1 (PD-L1) blocking antibody that works by helping the immune system recognize and attack cancer cells.

Directions

Tecentriq (Atezolizumab) is given intravenously (IV). The standard dosage for this medication is 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks. Subsequent doses are usually given every 3 weeks until disease progression or unacceptable toxicity levels are reached. Consult a healthcare professional before starting treatment, as they may adjust the dosage depending on the cancer being treated. Be aware that Tecentriq is often used in combination with other medications, such as bevacizumab, to treat specific types of cancer.

Ingredients

The active ingredient in Tecentriq is Atezolizumab. Alongside this primary ingredient, several inactive ingredients may be included in the formulation of Tecentriq.

Contraindications

There are no contraindications for Tecentriq indicated on the drug label. However, those with an allergy or hypersensitivity to Atezolizumab should avoid using the medication.

Cautions

• Before starting Tecentriq, speak with a healthcare provider about the following:
• Any underlying medical issues, especially those involving the immune system, a history of organ transplant, or any nervous system disorders.
• The full list of medications you are presently taking.
• Your current pregnancy status or intention to breastfeed.
• Being an immune checkpoint inhibitor, Tecentriq has the potential to hyperactivate the immune system, leading to inflammation and potential harm to organs. Should you experience symptoms such as fever, skin rash, joint pain, or increased fatigue, inform your doctor
• Tecentriq may not be appropriate for everyone. If you have experienced severe immune responses or allergies to medications of a similar kind, make sure to tell your healthcare professional..
• There is a possibility of reactions related to the infusion process, which might include fever, chills, difficulty breathing, or chest pain occurring during or after administration. Alert your healthcare provider right away if these symptoms arise.
• If you're noticing new or worsening symptoms like cough, stomach pain, skin changes, or anything else that's unusual for you, let your doctor know. You may undergo several tests before starting Tecentriq, and your health may be monitored regularly throughout the course of treatment.
• For those who have received or are planning to receive a donor stem cell transplant (allogeneic HSCT), be aware that using Tecentriq could cause serious and potentially fatal complications.

Side Effects

When taking Tecentriq (Atezolizumab), some individuals may encounter side effects. Common side effects may include fatigue, cough, nausea, diminished appetite, and difficulty in breathing. In addition, there may be general discomfort or pain in the body, feelings of dizziness, episodes of fever, and a frequent need to urinate.

Tecentriq may also lead to more severe side effects that require prompt medical treatment. These critical side effects can affect the lungs, intestines, liver, hormone-producing glands, kidneys, and skin, along with other organs. Some individuals may experience infusion reactions, which in rare cases could be significant or even life-threatening. In the event of any severe side effects, seek immediate medical assistance.

References

1. Tecentriq (Atezolizumab) Product Monograph. San Francisco, CA: Genentech, Inc; 2023.
2. Tecentriq (Atezolizumab) Drug Label Information. South San Francisco, CA: Genentech, Inc.; 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....