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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Trikafta (elexacaftor/tezacaftor/ivacaftor and ivacaftor) contains 3 medications for the treatment of cystic fibrosis in patients who are 2 years of age and older with one or more F508del mutations or another mutation in the CFTR gene that responds to treatment.
Trikafta is available in oral tablets:
Trikafta is also available in oral granules:
Trikafta should be taken as directed by your doctor. The instructions for use that accompany your prescription should be thoroughly read. Any questions or concerns may be referred to your doctor or pharmacist.
Your doctor will instruct you on how much Trikafta you should take and for how long, depending on your age, weight, and medical conditions. Trikafta should be taken with fatty food to aid its absorption into the body.
The active ingredients in Trikafta include elexacaftor/tezacaftor/ivacaftor.
Croscarmellose sodium, hypromellose, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, hydroxypropyl cellulose, hypromellose, iron oxide red, iron oxide yellow, talc, and titanium dioxide are the inactive ingredients in the elexacaftor, tezacaftor and ivacaftor fixed-dose combination tablets.
Colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium lauryl sulfate, carnauba wax, FD&C Blue #2, PEG 3350, polyvinyl alcohol, talc, titanium dioxide, ammonium hydroxide, iron oxide black, propylene glycol, and shellac are the inactive ingredients in the ivacaftor tablets.
Colloidal silicon dioxide, croscarmellose sodium, hypromellose, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, mannitol, sodium lauryl sulfate, and sucralose are the inactive ingredients in the elexacaftor, tezacaftor and ivacaftor fixed-dose combination oral granules.
Colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, mannitol, sodium lauryl sulfate, and sucralose are the inactive ingredients in the ivacaftor granules.
The most recent Prescribing Information does not list any contraindications to Trikafta. However, consult your healthcare provider about your treatment options.
Trikafta side effects include but are not limited to headache, upper respiratory tract infection, abdominal pain, diarrhea, rash, increased liver enzymes, nasal congestion, blood creatine phosphokinase increased, runny nose, rhinitis, influenza, sinusitis, and increased blood bilirubin. Immediately inform your doctor of any bothersome or persistent side effects.
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Trikafta. Boston, MA: Vertex Pharmaceuticals Incorporated; 2023.
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