Trintellix (Vortioxetine)

Also Known as Brintellix

Prescription medicineOnly Available By Prescription
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

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To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Trintellix is a medication primarily used to treat major depressive disorder (MDD) in adults. It belongs to the class of drugs known as serotonin modulators and stimulators (SMS), which work by enhancing the activity of serotonin, a neurotransmitter involved in mood regulation.

Unlike some antidepressants that primarily inhibit serotonin reuptake, Trintellix works via multiple mechanisms of action, including serotonin reuptake inhibition, receptor activity modulation, and neurotransmitter release enhancement, which may contribute to its efficacy in treating depression.


Fact Table

Formula

C18H22N2S

License

US DailyMed, EU EMA, US FDA

Bioavailability

75%

Legal status

Rx-Only

Chemical Name

Vortioxetine

Elimination half-life

66 hours

Dosage (Strength)

5mg, 10mg, 15mg, 20mg

Pregnancy

Not recommended

Brands

Trintellix

Protein binding

98–99%

PubChem CID

9966051

MedlinePlus

a614003

ChEBI

76016

ATC code

N06AX26

DrugBank

DB09068

KEGG

D10184

Routes of administration

By mouth

Directions

The usual dosage of Trintellix is 5-20 mg by mouth once daily with or without food.

Ingredients

The active ingredient in Trintellix is vortioxetine.

Interactions

Common drug-drug interactions may include:

  • Abciximab
  • Abiraterone Acetate
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Alfentanil
  • Almotriptan
  • Amineptine
  • Amiodarone
  • Amisulpride
  • Amoxapine
  • Amphetamine
  • Amitriptyline
  • Amitriptylinoxide
  • Apalutamide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Atazanavir
  • Bemiparin
  • Benzhydrocodone
  • Benzphetamine
  • Betrixaban
  • Bivalirudin
  • Bromfenac
  • Brompheniramine
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Buspirone
  • Butorphanol
  • Cangrelor
  • Carbamazepine
  • Celecoxib
  • Certoparin
  • Chlorpheniramine
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clonixin
  • Clopidogrel
  • Cocaine
  • Codeine
  • Cobicistat
  • Cyclobenzaprine
  • Dabigatran Etexilate
  • Dacomitinib
  • Dalteparin
  • Danaparoid
  • Darunavir
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Dextroamphetamine
  • Dextromethorphan
  • Dibenzepin
  • Diclofenac
  • Difenoxin
  • Diflunisal
  • Dihydrocodeine
  • Diphenoxylate
  • Dipyridamole
  • Dipyrone
  • Dolasetron
  • Doxepin
  • Drotrecogin Alfa
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Eletriptan
  • Enoxaparin
  • Enzalutamide
  • Epoprostenol
  • Eptifibatide
  • Escitalopram
  • Eslicarbazepine Acetate
  • Ethylmorphine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenfluramine
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosphenytoin
  • Frovatriptan
  • Gepirone
  • Granisetron
  • Heparin
  • Hydrocodone
  • Hydromorphone
  • Hydroxyamphetamine
  • Hydroxytryptophan
  • Ibuprofen
  • Iloprost
  • Imipramine
  • Indomethacin
  • Iobenguane I 131
  • Ivosidenib
  • Ketobemidone
  • Ketoprofen
  • Ketorolac
  • Lasmiditan
  • Lepirudin
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lorcaserin
  • Lornoxicam
  • Loxoprofen
  • Lumacaftor
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Meperidine
  • Metoclopramide
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methylene Blue
  • Methylphenidate
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Naproxen
  • Naratriptan
  • Nefazodone
  • Nepafenac
  • Nicomorphine
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Ozanimod
  • Oliceridine
  • Ondansetron
  • Opipramol
  • Opium
  • Opium Alkaloids
  • Oxaprozin
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Palonosetron
  • Papaveretum
  • Parecoxib
  • Paregoric
  • Parnaparin
  • Paroxetine
  • Phenelzine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Phenytoin
  • Piketoprofen
  • Piritramide
  • Piroxicam
  • Pixantrone
  • Pranoprofen
  • Prasugrel
  • Procarbazine
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quinidine
  • Rasagiline
  • Remifentanil
  • Reviparin
  • Ritonavir
  • Rofecoxib
  • Safinamide
  • Salicylic Acid
  • Salsalate
  • Selegiline

Cautions

Use Trintellix with caution if you have a history of suicidal thoughts or behaviors, bipolar disorder, seizures, or liver impairment.

It may increase the risk of suicidal thinking and behavior, particularly in young adults.

Regular monitoring for worsening depression or emergence of suicidal thoughts is recommended during treatment with Trintellix.

Side Effects

Common adverse reactions to Trintellix may include:

  • Abnormal hypersensitivity reaction
  • Constipation
  • Hemorrhage
  • Hyponatremia
  • Nausea
  • Sexual dysfunction
  • Serotonin syndrome
  • Vomiting

References

  1. Trintellix [package insert]. Deerfield, IL: Takeda; January 2021.

Frequently Asked Questions about Trintellix


What is Trintellix used for?

Trintellix is a prescription medication for treating major depressive disorder (MDD) in adults. It helps rebalance brain chemicals.


Why is Trintellix so expensive?

Trintellix's high cost reflects the extensive research and testing required to ensure its safety and effectiveness as a brand-name medication.


Does Trintellix cause weight gain?

While clinical trials didn't show significant weight changes, some users have reported weight gain after starting Trintellix.


Can you take more than 20 mg of Trintellix?

No, the safety and effectiveness of doses above 20 mg/day haven't been studied in controlled trials. The maximum dosage for treating depression is 20 mg/day.


How long does Trintellix take to work?

Most people notice some improvement after two weeks, but it may take four weeks or longer to experience the full benefits of Trintellix.


Is Trintellix a controlled substance?

No, Trintellix isn't classified as a controlled substance.


Can Trintellix help anxiety?

While not FDA-approved for anxiety, Trintellix has been used off-label for severe cases of generalized anxiety disorder (GAD).


What are the side effects of Trintellix?

Trintellix can cause a range of side effects, including nausea (the most common), as well as itching, weight gain, gastrointestinal issues, headaches, and more serious effects like serotonin syndrome or allergic reactions.


What exactly does Trintellix do?

Trintellix is believed to work as an antidepressant by increasing serotonin activity in the brain, primarily by blocking its reuptake.


What is the most common side effect of Trintellix?

Nausea is the most reported side effect of Trintellix use.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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