Truqap (Capivasertib)

Prescription medicineOnly Available By Prescription
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160mg
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200mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Truqap, known generically as Capivasertib, is a type of medicine that targets specific proteins in the body to help fight cancer. It works by blocking certain signals that cancer cells use to grow and multiply. Truqap is mainly used to treat some types of breast cancer, especially those that have hormone receptors that are positive (HR-positive) and do not have too much of a protein called HER2 (HER2-negative). This medicine is particularly helpful for cancers with changes in specific genes, such as PIK3CA, AKT1, or PTEN.

Fact Table

Formula

C26H37N5O2S

License

US FDA (pending), EMA (pending)

Bioavailability

64%

Legal status

Investigational (pending approval)

Chemical Name

Capivasertib

Elimination half-life

3.8 hours

Dosage (Strength)

400 mg tablets

Pregnancy

Consult a doctor (No data available)

Brands

Truqap

Protein binding

96.6%

PubChem CID

58427641

MedlinePlus

Not available

ChEBI

145697

ATC code

L01XE61

DrugBank

DB12481

KEGG

D11167

Routes of administration

Oral

Directions

Truqap is typically taken orally twice daily, around 12 hours apart, with or without food. It's important to take the medication at the same time every day. The regimen involves taking Truqap for 4 consecutive days, followed by a 3-day break each week. The tablets must be swallowed whole with water, not chewed, crushed, or split. The recommended dosage is typically 400 mg, but it's important to follow your healthcare provider's specific instructions.

Ingredients

Capivasertib is the active ingredient in Truqap.

Contraindications

Avoid taking this medication if you have a severe hypersensitivity or known severe allergic reaction to Capivasertib or any of its ingredients.

Cautions

  • Before starting treatment with Truqap, make sure to disclose the following to your healthcare provider:
    • Any existing health conditions
    • Known allergies
    • A complete list of medications you are currently using
    • Your status regarding pregnancy or breastfeeding
  • Truqap can significantly raise blood sugar levels. It is not suitable for patients with Type 1 diabetes or those who need insulin. Watch for symptoms like increased thirst or more frequent urination, and contact your doctor if these occur.
  • Check your blood sugar and hemoglobin A1C before starting Truqap and regularly during treatment. This is especially important if you have diabetes or are at risk for high blood sugar.
  • Diarrhea is common with Truqap and can be severe. Increase your fluid intake and start anti-diarrheal medication at the first sign of diarrhea. Your doctor might adjust your dosage or stop treatment depending on the severity.
  • Severe skin reactions can occur with Truqap, including conditions like erythema multiforme and DRESS. If you notice skin changes, get medical help right away. Treatment might include corticosteroids and possibly discontinuing Truqap.
  • Truqap can harm an unborn baby. Women who could get pregnant should use effective contraception during treatment and for one month afterward. Men should use contraception during treatment and for four months after the final dose to avoid harming a potential pregnancy.

Side Effects

Truqap side effects include nausea, vomiting, and tiredness. Some people may also experience mouth sores or notice changes in their blood tests. These side effects are generally manageable and should be monitored by your healthcare provider.

Serious side effects from Truqap include high blood sugar levels, where symptoms can range from excessive thirst and dry mouth to confusion and a fruity odor on the breath. If you have diabetes, you’ll need close monitoring. Diarrhea is another serious side effect that could lead to dehydration; report any signs of loose or watery stools to your healthcare provider immediately. Skin reactions such as rashes, blistering, or peeling need urgent medical attention. Depending on the severity, your treatment may be adjusted or stopped to manage these serious side effects.

References

  1. Truqap (Capivasertib) Product Monograph. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2023.
  2. Truqap (Capivasertib) Drug Label Information. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2023.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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