Also Known as Vastarel MR
Top brand choice
Strength | Pack Size | Qty | |
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Strength
35mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
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Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vastarel MR is a prescription medication used to manage angina. Trimetazidine improves myocardial glucose utilization and inhibits fatty acid oxidation, thus optimizing cellular energy metabolism. This mechanism helps protect the heart from ischemia or insufficient blood supply, making it particularly beneficial for individuals with angina pectoris and related conditions.
Fact Table | |
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Formula | C14H22N2O3 · 2HCl |
License | Approved in various countries (not FDA approved) |
Bioavailability | Approximately 90% |
Legal status | Prescription only |
Chemical Name | 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride |
Elimination half-life | Approximately 6 hours |
Dosage (Strength) | 35 mg modified-release tablets |
Pregnancy | Not recommended; consult a healthcare provider |
Brands | Vastarel MR, Trimetazidine MR |
Protein binding | Approximately 16% |
PubChem CID | 144204 |
MedlinePlus | Not available |
ChEBI | 45949 |
ATC code | C01EB15 |
DrugBank | DB09149 |
KEGG | D07162 |
Routes of administration | Oral |
The usual dosage is 35 mg by mouth twice daily with meals.
The active ingredient in Vastarel MR is trimetazidine.
Drug-drug interactions for Vastarel MR are not well known. Based on how this drug works, it is likely to interact with antipsychotics, antihypertensives, and medications for angina. Example include:
Vastarel MR has not been approved for use in the United States but has been approved in other countries. The European Medicines Agency (EMA) recommends that it be no longer used for tinnitus, vertigo, or vision disturbances.
The EMA recommends caution when prescribing this drug to people with movement disorders like Parkinson's disease, parkinsonian symptoms, tremors, restless legs syndrome (RLS), and other movement disorders.
The most common side effects are:
Vastarel MR [package insert]. Giddy, France: Les Laboratories; February 2021.