Velcade (Bortezomib)

Prescription medicineOnly Available By Prescription
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3.5mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Velcade is a prescribed medication primarily used to address multiple myeloma, a form of cancer impacting plasma cells in the bone marrow. Additionally, it serves as a treatment for mantle cell lymphoma, an uncommon type of non-Hodgkin's lymphoma.

Bortezomib, the active component in Velcade, belongs to the proteasome inhibitor class of drugs. It hinders the function of proteasomes, which are cellular structures responsible for protein breakdown. By blocking proteasomes, it disrupts cancer cell growth and survival.

Fact Table
Formula C19H25BN4O4
License FDA approved
Bioavailability Approximately 64% (subcutaneous), 100% (intravenous)
Legal status Prescription only
Chemical Name (1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butylboronic acid
Elimination half-life Approximately 9 to 15 hours
Dosage (Strength) 3.5 mg/vial for injection
Pregnancy Not recommended; consult a healthcare provider
Brands Velcade
Protein binding Approximately 83%
PubChem CID 387447
MedlinePlus a605007
ChEBI 49575
ATC code L01XX32
DrugBank DB00188
KEGG D03497
Routes of administration Intravenous, Subcutaneous

Directions

Take Velcade exactly as prescribed by your healthcare provider. It is administered only by trained healthcare professionals.

Ingredients

The active ingredient in Velcade is bortezomib.

Interactions

Tell your doctor and pharmacist if you are taking any of the following:

  • Adenovirus Vaccine, Live
  • Apalutamide
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Carbamazepine
  • Cholera Vaccine, Live
  • Dengue Tetravalent Vaccine, Live
  • Ebola Zaire Vaccine, Live
  • Enzalutamide
  • Fosphenytoin
  • Influenza Virus Vaccine, Live
  • Itraconazole
  • Levoketoconazole
  • Lumacaftor
  • Measles Virus Vaccine, Live
  • Methotrexate
  • Mitotane
  • Mumps Virus Vaccine, Live
  • Phenytoin
  • Poliovirus Vaccine, Live
  • Rifampin
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Smallpox Monkeypox Vaccine, Live Non-Replicating
  • Smallpox Vaccine
  • St John's Wort
  • Typhoid Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Yellow Fever Vaccine

Cautions

Before starting Velcade, review your medical conditions or concerns with your healthcare provider. Inform your doctor of any history of peripheral neuropathy, heart disease, liver disease, kidney disease, lung disease, or herpes zoster.

Avoid using Velcade if you are pregnant or planning to become pregnant.

Side Effects

Common adverse reactions to be aware of include:

  • Anemia, All grades
  • Arthralgia
  • Asthenia
  • Bone pain
  • Constipation
  • Cough
  • Cramp
  • Diarrhea
  • Dizziness
  • Dyspnea
  • Dysesthesia
  • Fatigue
  • Fever
  • Headache
  • Heart disease
  • Heart failure
  • Leukopenia, All grades
  • Loss of appetite
  • Lower respiratory tract infection
  • Lymphocytopenia, All grades
  • Myalgia
  • Nausea
  • Neuralgia
  • Neutropenia, All grades
  • Paresthesia
  • Peripheral neuropathy
  • Rash
  • Thrombocytopenia, All grades
  • Vomiting

References

Velcade [package insert]. Cambridge, MA: Millennium Pharmaceuticals; June 2008.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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