Vesanoid (Tretinoin)

Description

Vesanoid, which is also called Tretinoin, is a medication used mainly to treat a type of cancer known as acute promyelocytic leukemia (APL). It belongs to a group of drugs called retinoids, which are related to vitamin A. Tretinoin works by helping immature blood cells in APL mature properly so they can function like healthy cells again. This medicine is available in the form of a 10 mg soft gelatin capsule that you take by mouth.

Directions

The recommended dosage of Vesanoid (Tretinoin) is 22.5 mg for every square meter of your body, taken by mouth twice a day until you achieve complete remission or for a maximum of 90 days. Swallow the capsules whole with a full glass of water and try to take them at the same time each day. If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose; in that case, skip the missed dose.

Ingredients

The active ingredient in Tretinoin is Vesanoid.

Contraindications

Avoid using this medication if you have a history of allergic reactions to Tretinoin, any of its components, or other retinoids.

Cautions

• Before using Vesanoid, ensure you provide your healthcare provider with the following information:
• Existing health conditions
• Known allergies
• A list of all the medications you are currently taking
• Your pregnancy or breastfeeding status

• Vesanoid can harm an unborn baby, leading to birth defects or miscarriage. Women who can become pregnant and men with partners of reproductive potential should use effective contraception during treatment and for some time after it ends.
• Differentiation syndrome is a serious condition that can arise soon after starting Vesanoid. Watch for symptoms like difficulty breathing, unusual weight gain, and fever. If these occur, seek immediate medical attention and possible steroid treatment.
• If you have high white blood cell counts, Vesanoid may increase these levels. Your doctor might consider additional treatments to manage this risk.
• Symptoms such as headaches, vomiting, or vision changes could indicate raised pressure in your skull, a potential side effect of Vesanoid. Seek medical evaluation for these symptoms.
• Regular blood tests to check your lipid levels are important since Vesanoid may cause significant increases.
• Monitor your liver function regularly as Vesanoid can cause liver enzyme elevations. Adjustments to your treatment may be necessary if liver issues arise.
• Watch for signs of blood clots like sudden chest pain or changes in vision, particularly during the initial treatment phase.

Side Effects

Vesanoid may cause side effects like headaches, fever, bone pain, and general feelings of discomfort. People may also experience dryness of skin and mucous membranes, respiratory symptoms such as difficulty breathing, and gastrointestinal problems including nausea, vomiting, and abdominal pain. These effects are typically related to the body’s reaction to the medication.

More severe reactions can occur with Vesanoid, including differentiation syndrome characterized by fever and difficulty breathing, and leukocytosis, which is an increase in white blood cell count. Patients may also experience intracranial high blood pressure, significant liver issues, and thromboembolic events such as blood clots. If you experience intense pain, severe stomach pain, or sudden changes in mental state, contact your healthcare provider immediately.

References

1. Vesanoid (Tretinoin) Product Monograph. Montgomery, AL: H2-Pharma, LLC; 2023.
2. Vesanoid (Tretinoin) Drug Label Information. Montgomery, AL: H2-Pharma, LLC; 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....