Vyloma (Imiquimod)

Description

Vyloma, known by the generic name Imiquimod, is a topical cream classified as an immune response modifier. It activates the immune system to treat external genital and perianal warts. It works by prompting the body to produce interferon and other cytokines, substances that play a role in fighting viruses.

Directions

Vyloma is typically applied in a thin layer directly to the affected area of the skin just before bedtime. It’s crucial to rub the cream in gently until it's absorbed. After application, leave the medicine on the skin for approximately 8 hours, which involves avoiding water on the treated area during this period. After the treatment time has elapsed, patients should wash the area with mild soap and water. Treatment usually lasts for up to eight weeks.

Ingredients

The main active ingredient in Vyloma is Imiquimod.

Contraindications

Avoid taking or using this medication if you have a known hypersensitivity or allergy to Imiquimod or any component of the formulation.

Cautions

• Speak with a healthcare provider about the following before using Vyloma cream:
• Any allergies you may have
• If you are currently pregnant or breastfeeding
• Any other medical conditions you have
• Any medications you are currently using
• Vyloma shouldn't be used to treat HPV infections that are inside the urethra, vagina, cervix, rectum, or inside the anus. These areas are particularly sensitive and not suitable for treatment with Vyloma.
• Applying Vyloma can lead to skin reactions where it's applied. These include redness, scabs or crusts forming, skin flaking or scaling, dryness, and swelling. Sometimes, these reactions can be quite strong, possibly needing you to pause your treatment.
• Applying Vyloma to the external areas of female genitalia may cause significant swelling, which in rare cases, could make it hard to urinate. If this severe swelling happens, you may need to stop using Vyloma temporarily or altogether.
• Before using Vyloma, ensure any skin area previously treated with other medications or procedures is fully healed. If you experience a severe reaction on the skin, wash the area with soap and water, and consult your doctor about possibly halting treatment until the reaction has improved.
• In addition to local skin reactions, Vyloma may cause symptoms throughout your body similar to the flu, such as fatigue, feeling sick, fever, muscle and joint aches, and chills. If these symptoms become bothersome, a discussion with your doctor about adjusting your treatment may be necessary.
• Research in animals indicates that Vyloma might increase the risk of skin tumor development if the treated area is exposed to UV light from the sun or other sources. It's best to limit or avoid exposing treated skin to sunlight.
• The safety of Vyloma for people with compromised immune systems, existing autoimmune diseases, or known hypersensitivity to its ingredients hasn't been fully established. If you experience an allergic reaction, stop using Vyloma immediately and seek medical advice.
• The effects of Vyloma during pregnancy or nursing are not fully known. If you're pregnant, thinking about becoming pregnant, or nursing, use Vyloma only if absolutely necessary and after discussing it with your doctor.
• The effectiveness and safety of Vyloma for individuals under 18 years old have not been confirmed. For those over 65, while data is limited, extra caution is advised due to possible increased sensitivity.

Side Effects

Vyloma is known to cause a variety of skin reactions at the site of application, such as redness, swelling, sores, ulcers, pain, irritation, and changes in skin color that may be permanent. Other effects include skin thickening, peeling, scabbing, itching, burning, bleeding, and discharge. Patients may also experience systemic effects like pain, fever, muscle and joint aches, fatigue, flu-like symptoms, headache, nausea, and diarrhea. The appearance of the skin in the treated area will likely differ from untreated skin until it has fully healed.

Severe skin reactions that interfere with daily activities or do not resolve may occur, indicating a need to stop using the cream and consult a healthcare provider. Overuse or incorrect application increases the risk of these reactions. Hypersensitivity reactions, such as difficulty breathing, swelling, and severe rashes, require immediate discontinuation of the cream and urgent medical attention. While treating, new warts may emerge, and the cream might not completely prevent their recurrence. If experiencing excessive or concerning side effects, especially within the first week of treatment or if flu-like symptoms or general discomfort arises, discontinue the medication and seek medical advice.

References:

1. Vyloma (Imiquimod) Product Monograph. Laval, Quebec: Bausch Health; 2019.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....