Wellbutrin SR (Bupropion)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Strength
150mg
Pack Size
Qty
Strength
200mg
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Top Generic choice

Strength Pack Size Qty
Strength
100mg
Pack Size
Qty
Strength
150mg
Pack Size
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Strength
200mg
Pack Size
Qty
What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Wellbutrin SR is a brand name for a medication called Bupropion Hydrochloride, which is used to treat depression. It is different from many other antidepressants because it works in a unique way, not fitting into common categories like tricyclics or selective serotonin reuptake inhibitors (SSRIs). Wellbutrin SR helps balance certain chemicals in the brain, such as dopamine and norepinephrine, which may play a role in managing mood and behavior.

Fact Table

Formula

C13H18ClNO

License

US FDA

Bioavailability

5-20%

Legal status

Prescription only (Rx)

Chemical Name

Bupropion hydrochloride

Elimination half-life

21 hours

Dosage (Strength)

100 mg, 150 mg, 200 mg (sustained-release tablets)

Pregnancy

Category C (Risk not ruled out; consult a doctor)

Brands

Wellbutrin SR, Zyban, Budeprion SR

Protein binding

84%

PubChem CID

444

MedlinePlus

a695033

ChEBI

CHEBI:3216

ATC code

N06AX12

DrugBank

DB01156

KEGG

D07574

Routes of administration

Oral

Directions

Wellbutrin SR should be taken exactly as prescribed by a healthcare provider. The standard Wellbutrin SR dosage for adults is typically 150 mg taken once daily in the morning. It’s crucial that these tablets are swallowed whole—crushing, dividing, or chewing them can increase the risk of side effects. After three days, if the healthcare provider recommends, the dosage may then be increased to 150 mg twice daily, with doses at least 8 hours apart to minimize the risk of seizures. While Wellbutrin SR can be taken with or without food, consistent use helps maintain an even level of medication in the body.

Ingredients

The active ingredient in Wellbutrin SR is Bupropion.

Contraindications

Avoid taking or using this medication if any of the following apply:

  • History of seizure disorder
  • Current or past diagnosis of bulimia or anorexia nervosa
  • Sudden withdrawal from alcohol, benzodiazepines, barbiturates, or antiepileptic medications
  • Use of monoamine oxidase inhibitors (MAOIs) for psychiatric conditions, either concurrently or within 14 days of stopping
  • Wellbutrin SR Known allergy to Bupropion or any other components of Wellbutrin SR

Cautions

  • Before taking Wellbutrin SR, tell your healthcare provider about the following:
    • Any existing health conditions
    • Any allergies
    • A list of all medications you are currently taking
    • Whether you are pregnant or breastfeeding
  • Wellbutrin SR, like other antidepressants, may increase the risk of suicidal thoughts or actions in children, adolescents, and young adults, especially in the first few months of treatment or after dose changes. If you or someone you know experiences worsening depression, unusual mood changes, or thoughts of self-harm, seek medical help immediately.
  • Some people taking Wellbutrin SR have reported increased anxiety, agitation, hostility, impulsivity, or mania. If you notice unusual mood swings or erratic behavior, contact your doctor right away.
  • Wellbutrin SR can increase the risk of seizures, especially at higher doses. The risk is also greater for those with a history of seizures, eating disorders like anorexia or bulimia, alcohol or drug withdrawal, or those taking other medications that lower the seizure threshold. If you have a seizure while taking this medication, stop using it and call your doctor immediately.
  • In rare cases, Wellbutrin SR has been linked to symptoms like paranoia, delusions, or hallucinations, particularly in people with bipolar disorder. If you experience any of these symptoms, seek medical attention.
  • Antidepressants, including Wellbutrin SR, can trigger mania or hypomania in people with bipolar disorder. Your doctor may screen for bipolar disorder before prescribing this medication.
  • Wellbutrin SR may cause eye issues like increased pressure, which could lead to angle-closure glaucoma. If you experience sudden eye pain, vision changes, or swelling around the eyes, seek medical care immediately.
  • Although Wellbutrin SR contains the same ingredient as Zyban, which is used for smoking cessation, this medication is not approved for that purpose. Some people taking Bupropion for smoking cessation have reported mood changes, aggression, paranoia, and suicidal thoughts. If you experience these symptoms, contact a healthcare provider immediately.

Side Effects

The most common side effects of Wellbutrin SR include headache, dry mouth, nausea, dizziness, and constipation. Some people may also experience trouble sleeping, sore throat, or an upset stomach. These side effects are usually mild and tend to improve as the body adjusts to the medication. If any of these symptoms become severe or do not go away, talk to a healthcare provider.

Wellbutrin SR may increase the risk of seizures, particularly at higher doses or in individuals with certain medical conditions. Some people may also experience mood changes, including agitation, aggression, or suicidal thoughts, especially at the start of treatment. Rare but serious reactions include high blood pressure, visual disturbances, or severe allergic reactions such as swelling of the lips, tongue, or throat. If you experience hallucinations, manic episodes, or unusual thoughts or behaviors, contact a healthcare provider immediately.

References

  1. Wellbutrin SR (Bupropion) Product Monograph. Durham, NC: GlaxoSmithKline; 2024.
  2. Wellbutrin SR (Bupropion) Drug Label Information. Durham, NC: GlaxoSmithKline; 2024.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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