Xpovio (Selinexor)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Xpovio (selinexor) is taken with other medications for the treatment of multiple myeloma in adults. It may also be used for the treatment of relapsed or refractory diffuse large B-cell lymphoma in adults.

Xpovio 20 mg, 40 mg, 50 mg, and 60 mg tablets are available for oral administration with a valid prescription.

Fact Table

Formula

C17H11Cl2F6N3O

License

US FDA

Bioavailability

59%

Legal status

Prescription only (Rx)

Chemical Name

(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N-(pyrazin-2-yl)acrylamide

Elimination half-life

6-8 hours

Dosage (Strength)

20 mg, 40 mg, 50 mg tablets

Pregnancy

Contraindicated

Brands

Xpovio

Protein binding

95%

PubChem CID

16720740

MedlinePlus

a619045

ChEBI

134722

ATC code

L01XX62

DrugBank

DB11702

KEGG

D10819

Routes of administration

Oral

Directions

Xpovio should be taken as directed by your doctor. Your doctor will tell you how much medication you should take. Xpovio is typically taken 1-2 times per week.

Keep Xpovio tablets stored at 30°C (86°F) or lower and out of reach of children.

Consult the medication guide included with your Xpovio prescription for further usage instructions.

You may refer any questions or concerns to your doctor or pharmacist.

Ingredients

Selinexor is the active ingredient in Xpovio.

Colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, Opadry 200 clear, Opadry II blue, povidone K30, and sodium lauryl sulfate are the inactive ingredients included.

Contraindications

There are no listed contraindications per the most recent Prescribing Information.

Cautions

  • Before you start taking Xpovio, inform your doctor of the following:
    • All the medications you take, including prescription and nonprescription medications
    • Your allergies
    • Your existing health conditions
    • Your previous medical history
    • If you are pregnant or breastfeeding
  • Xpovio contains following warnings and precautions:
    • Decreased platelet and neutrophil counts
    • Stomach and intestinal toxicity that can cause nausea, vomiting, diarrhea, anorexia, and weight loss
    • Decreased sodium levels in the blood
    • Potentially serious infections
    • Neurological problems; driving and participating in other hazardous activities should be avoided until you know how you are affected by the medication
    • Fetal harm; effective contraception is recommended during Xpovio treatment and for 1 week after taking the final dose in females of reproductive ability and males with female partners of reproductive ability
    • Cataracts
    • Breastfeeding is not recommended

Side Effects

Xpovio side effects include but are not limited to fatigue; decreased appetite; nausea; vomiting; diarrhea; upper respiratory tract infection; nerve problems that can cause pain, numbness, or tingling; decreased weight; cataracts; low platelets; low sodium levels in the blood; low phosphate levels in the blood; low neutrophils, leukocytes, and lymphocytes; constipation; anemia; fever; and shortness of breath.

If you experience bothersome or persistent side effects, contact your doctor right away.

Looking for a Xpovio cost that’s competitive? Here, you can buy Xpovio with a valid prescription.

Reference

Xpovio. Newton, MA: Karyopharm Therapeutics Inc.; 2022.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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