Zejula (Niraparib)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
100mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Zejula is a prescription medication prescribed for certain types of cancer, specifically ovarian, fallopian tube, and primary peritoneal cancer. It is specifically prescribed for patients with recurrent cancer who have responded to platinum-based chemotherapy.

Zejula belongs to a class of drugs known as PARP (poly ADP-ribose polymerase) inhibitors. These drugs work by blocking the PARP enzyme involved in DNA repair. This inhibition prevents cancer cells from repairing their DNA, leading to cell death and slowing disease progression.

Fact Table
Formula C19H20N4O5
License FDA approved
Bioavailability High (well absorbed orally)
Legal status Prescription only
Chemical Name 2-(4-{[3-(4-Morpholinyl)phenyl]carbonyl}piperazin-1-yl)-2H-indazole-7-carboxamide
Elimination half-life Approximately 36 hours
Dosage (Strength) 100 mg capsules
Pregnancy Not recommended; consult a healthcare provider
Brands Zejula
Protein binding Approximately 83%
PubChem CID 24958200
MedlinePlus a617019
ChEBI 134724
ATC code L01XX54
DrugBank DB11793
KEGG D10761
Routes of administration Oral

Directions

The usual dose is 200-300 mg ( 100 mg capsules) once daily. The dosage may be adjusted based on the patient’s weight, platelet count, and overall health.

Zejula may be taken with or without food.

Ingredients

The active ingredient in Zejula is niraparib.

Interactions

There are no significant drug-drug interactions with Zejula

Cautions

Zejula has been associated with cases of myelodysplastic syndrome/acute myeloid leukemia (MDS/AML), some of which have been fatal. Your doctor should monitor for hematological toxicity and discontinue the medication if MDS/AML is confirmed.

Bone marrow suppression is another significant risk. Your doctor should monitor complete blood counts every week for one month, monthly for the next eleven months, and periodically thereafter to monitor for clinically significant changes.

Changes in blood pressure and heart rate can occur. Patients should have their blood pressure and heart rate monitored at least weekly for the first two months, then monthly for the first year, and periodically after that. Management may include the use of antihypertensive medications and adjustments to the Zejula dose if necessary.

Tell your doctor if you are pregnant or planning to become pregnant.

Side Effects

The most common side effects include:

  • Acute myeloid leukemia
  • Anemia
  • Anemia, Grade 3 or 4
  • Constipation
  • Decrease in appetite
  • Dyspnea
  • Gastrointestinal perforation
  • Headache
  • Hypertension
  • Hypertensive crisis
  • Insomnia
  • Leukopenia, Grade 3 or 4
  • Myelodysplastic syndrome
  • Nasopharyngitis
  • Nausea
  • Neutropenia
  • Neutropenia, Grade 3 or 4
  • Pancytopenia
  • Perforation of small intestine
  • Pleural effusion
  • Posterior reversible encephalopathy syndrome
  • Rash
  • Thrombocytopenia
  • Thrombocytopenia, Grade 3 or 4
  • Vomiting

References

Zejula [package insert]. Research Park Triangle, NC: GlaxoSmithKline; April 2020.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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