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Strength
50mg/100mg
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zepatier (elbasvir and grazoprevir) is a medication prescribed for treating chronic hepatitis C virus genotype 1 or 4 infection in adults and pediatric patients who are 12+ years of age and weigh 30+ kg. It may be administered with ribavirin in certain patients.
Zepatier oral tablets contain 50 mg elbasvir and 100 mg grazoprevir.
| Fact Table | |
| Formula | C49H55N9O7 (Elbasvir), C38H50N6O9S (Grazoprevir) |
| License | US FDA, EMA |
| Bioavailability | 32% (Elbasvir), 27% (Grazoprevir) |
| Legal status | Prescription only (Rx) |
| Chemical Name | Elbasvir: N-[(6S)-6-{[(5S)-5-(Methoxycarbonyl)-4-methyl-1,3-thiazol-2-yl]carbamoyl}-2-(4-methylphenyl)tetrahydro-2H-pyran-3-yl]-1H-indole-3-carboxamide, Grazoprevir: (1R,18R,20S,24S)-20-tert-butyl-N-[(1R,2S)-1-{[(2S)-3-tert-butylsulfonyl-2-pyrrolidinyl]amino}-1-(cyclopropylsulfonyl)-2-methylpropyl]-18-(2-carbamimidamidoacetamido)-2,5-dioxo-1,3,4,5,20,22,23,24-octahydro-2,21-diazapentacene-3-carboxamide |
| Elimination half-life | 24 hours (Elbasvir), 31 hours (Grazoprevir) |
| Dosage (Strength) | Elbasvir 50 mg/Grazoprevir 100 mg tablets |
| Pregnancy | Consult a doctor |
| Brands | Zepatier |
| Protein binding | 99.9% (Elbasvir), 98.8% (Grazoprevir) |
| PubChem CID | 54767912 (Elbasvir), 54767914 (Grazoprevir) |
| MedlinePlus | a616026 |
| ChEBI | 142593 (Elbasvir), 859133 (Grazoprevir) |
| ATC code | J05AP56 |
| DrugBank | DB11574 (Elbasvir), DB11575 (Grazoprevir) |
| KEGG | D10766 (Elbasvir), D10767 (Grazoprevir) |
| Routes of administration | Oral |
Take Zepatier as your doctor has prescribed.
Recommended dosing: one tablet by mouth one time a day with or without food.
Store Zepatier in the original packaging between 20°C and 25°C (68°F and 77°F).
For additional usage instructions, consult the medication guide included with your prescription.
You may refer any questions or concerns to your doctor or pharmacist.
Elbasvir and grazoprevir are the active ingredients in Zepatier.
Colloidal silicon dioxide, copovidone, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, mannitol, microcrystalline cellulose, sodium chloride, sodium lauryl sulfate, vitamin E polyethylene glycol succinate, carnauba wax, ferrosoferric oxide, hypromellose, iron oxide red, iron oxide yellow, lactose monohydrate, titanium dioxide, and triacetin are the inactive ingredients.
Zepatier should not be given to patients with moderate or severe liver dysfunction.
Zepatier should not be taken with OATP1B1/3 inhibitors that can significantly increase grazoprevir plasma concentrations, strong CYP3A4 inducers, and efavirenz. Talk to your doctor about whether you take these medications.
If you are also taking ribavirin, its contraindications also apply. Consult your doctor or pharmacist about any contraindications you may have.
Zepatier medication side effects include but are not limited to headache, fatigue, and nausea.
Tell your doctor right away if you have bothersome or persistent side effects.
Looking for a competitive price of Zepatier? Here, you can buy Zepatier with a valid prescription!
Zepatier. Rahway, NJ: Merck Sharp & Dohme LLC; 2022.
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