Zoryve (Roflumilast)

Prescription medicineOnly Available By Prescription
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0.3% Foam Can
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0.3% Cream Tube
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Zoryve (roflumilast) cream is prescribed to treat patients who are 6 years old or older with plaque psoriasis. It is for topical use.

Zoryve comes in 60-gram tubes that contain 3 mg of roflumilast per gram.

Fact Table
Formula C17H14Cl2F2N2O3
License FDA approved
Bioavailability Approximately 80%
Legal status Prescription only
Chemical Name 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Elimination half-life Approximately 17 hours (for Roflumilast) and 30 hours (for the active metabolite, Roflumilast N-oxide)
Dosage (Strength) 0.3% topical cream
Pregnancy Consult a healthcare provider; limited data available
Brands Zoryve
Protein binding 99%
PubChem CID 449190
MedlinePlus a611027
ChEBI 71102
ATC code D11AH07
DrugBank DB01656
KEGG D01208
Routes of administration Topical

Directions

Zoryve should be used as your or your child’s doctor prescribes. It is recommended to apply the cream to the affected areas of the skin once daily.

Avoid contact with the mouth, eyes, or vaginal areas.

Zoryve cream should be kept between 20°C and 25°C (68°F and 77°F); keep out of reach of children.

There is a medication guide that comes with the prescription that can be referred to for more instructions on administration.

Speak to your or your child’s doctor or pharmacist if you have any questions or concerns.

Ingredients

Roflumilast is the active ingredient in Zoryve.

Inactive ingredients include the following: ceteareth-10 phosphate, cetearyl phosphate, cetostearyl alcohol, diethylene glycol monoethyl ether, hexylene glycol, isopropyl palmitate, methylparaben, propylparaben, purified water, sodium hydroxide, and white petrolatum. Hydrochloric acid may be added to balance the pH.

Contraindications

Zoryve cream is contraindicated in patients with moderate to severe liver impairment.

Cautions

  • Before you or your child starts using Zoryve, tell the doctor if you or your child:
    • Take any prescription or nonprescription medications
    • Have any allergies
    • Have any current or past medical conditions
    • Are pregnant or breastfeeding

Side Effects

Some, but not all, Zoryve cream side effects include diarrhea, headache, sleeping issues, pain at the application site, upper respiratory tract infections, and urinary tract infections.

If you or your child experience bothersome or persistent side effects, immediately talk to a doctor.

Here, you can buy Zoryve cream!

Reference

Zoryve cream. Westlake Village, CA: Arcutis Biotherapeutics, Inc.; 2024.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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