Zydelig (Idelalisib)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
100mg
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Strength
150mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Zydelig is a prescription medication primarily utilized in the treatment of certain types of blood cancers, particularly chronic lymphocytic leukemia (CLL), B-cell non-Hodgkin lymphoma (HL), and relapsed small lymphocytic lymphoma (SLL).

Zydelig belongs to a class of drugs known as phosphoinositide 3-kinase (PI3K) inhibitors. By targeting specific enzymes involved in the development and survival of cancer cells, Zydelig helps slow down cancer progression and improves patient health outcomes.

Fact Table
Formula C22H18FN7O
License FDA approved
Bioavailability Approximately 57%
Legal status Prescription only
Chemical Name 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4(3H)-one
Elimination half-life Approximately 8.2 hours
Dosage (Strength) 100 mg, 150 mg tablets
Pregnancy Not recommended; consult a healthcare provider
Brands Zydelig
Protein binding Approximately 93%
PubChem CID 11625830
MedlinePlus a614050
ChEBI 85967
ATC code L01XX47
DrugBank DB09054
KEGG D10216
Routes of administration Oral

Directions

The usual starting dose is 150 mg by mouth twice daily.

Ingredients

The active ingredient in Zydelig is idelalisib.

Interactions

Common drug-drug interactions with Zydelig may include:

  • Alfuzosin
  • Alprazolam
  • Colchicine
  • Conivaptan
  • Dihydroergotamine
  • Dronedarone
  • Eletriptan
  • Eliglustat
  • Eplerenone
  • Ergotamine
  • Finerenone
  • Gepirone
  • Isavuconazonium Sulfate
  • Ivabradine
  • Lomitapide
  • Lovastatin
  • Lurasidone
  • Maraviroc
  • Mavacamten
  • Naloxegol
  • Pacritinib
  • Pimozide
  • Ranolazine
  • Silodosin
  • Simvastatin
  • Tolvaptan
  • Triazolam
  • Ubrogepant
  • Venetoclax
  • Voclosporin

Cautions

Before starting treatment, tell your doctor if you have a history of kidney or liver problems.

Zydelig can cause skin reactions. If you experience a severe skin reaction, stop taking the drug and tell your healthcare provider right away.

Your doctor should monitor the levels of your blood cells during treatment.

Do not take this drug if you are pregnant or planning to become pregnant. Do not take this drug if you are breastfeeding.

Zydelig has many potential drug-drug interactions. Before starting this drug, discuss your entire medication list with your pharmacist and doctor.

Side Effects

The most common adverse reactions may include:

  • Anaphylaxis
  • Colitis
  • Cough
  • Cytomegalovirus infection
  • Diarrhea
  • Drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Erythroderma
  • Fatigue
  • Febrile neutropenia
  • Fever
  • Hepatotoxicity, serious or fatal
  • Hypersensitivity reaction
  • Increased liver enzymes
  • Infectious disease
  • Nausea
  • Neutropenia, All Grades
  • Neutropenia, Grade 3 or 4
  • Perforation of intestine
  • Pneumocystis jirovecii present
  • Pneumonia
  • Pneumonitis
  • Rash
  • Sepsis
  • Shivering
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis

References

Zydelig [package insert]. Foster City, CA: Gilead; July 2014.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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